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NEXT LIPIDS ΩNLINE WEBINAR IS: REGISTRATION OPENING SOON!
REMAINING 2021 LIPIDS ΩNLINE WEBINAR SCHEDULE:
JUNE 16, 2021 WEBINAR: "Bioactive lipids: an overview of their structure and functions." Abstract: Lipids are a large and structurally diverse group of organic compounds for which there is no internationally accepted definition, and so are often grouped based on different criteria, including their solubility in organic solvents, their structure and functions, or their chemical structures, for example, fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, prenol lipids, saccharolipids, and polyketides. This presentation will provide an overview of the structure and functions of bioactive and physiologically important lipids.
PREVIOUS LIPIDS ΩNLINE WEBINAR RECORDINGS "Obesity drives a signature of SPM precursor deficiency: Implications for glucose homeostasis and infection" Abstract: Obesity is associated with a wide range of complications including, but not limited to, chronic inflammation, insulin resistance, cardiovascular diseases, and increased susceptibility to infections. Therefore, there is a critical need to investigate how metabolic changes associated with obesity contribute toward differing complications. I will first cover evidence to show that obesity generally drives a deficiency in the concentration of metabolites of the specialized pro-resolving mediator (SPM) family. Then, I will present examples of how administration of SPMs to obese mice can reverse these deficiencies and thereby improve glucose homeostasis and humoral immunity upon influenza infection. Finally, the talk will underscore how addressing key gaps in knowledge will allow us to effectively translate SPMs and their parent polyunsaturated fatty acids toward precision clinical trials. These include establishing sex-differences in SPM levels and potential genetic differences in SPM metabolism in the context of a heterogenous population with obesity. Overall, SPM deficiencies are a key hook between obesity and impaired metabolic and infectious outcomes. Did you miss the 17 March webinar? It will be posted below in the Archive for 30 days. Webinars are typically posted within 24 hours of completion. All webinars will be in the ISSFAL Members Only section permanently. LIPIDS ΩNLINE ARCHIVE "Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway" Abstract: The n-3 polyunsaturated fatty acids (PUFA) are important for regulating brain, heart, and immune function, among others. While the general principles of the n-3 PUFA synthesis pathway (i.e, that alpha-linolenic acid (ALA; 18:3n-3) can be converted to docosahexaenoic acid (DHA; 22:6n-3)) are generally agreed upon, some controversy in the details remain. In this talk I will provide updates on the synthesis of DHA from precursors, including the Sprecher intermediate tetracosahexaenoic acid (THA; 24:6n-3), as well as the retroconversion of DHA to eicosapentaenoic acid (EPA; 20:5n-3). While much of the work has been completed in preclinical models, recent translational studies will also be discussed. In conclusion, this talk hopes not only to address some controversies in n-3 PUFA synthesis but to also raise a few new ones for future research. "Unraveling the Effects of Fatty Acids on Inflammation" Abstract: This seminar will describe inflammation, its role in immune defense and how it is linked to many different health conditions. Then the role of different fatty acids in creating an environment which favours or dampens inflammation will be described. Effects of saturated, omega-6 and omega-3 fatty acids will be discussed. The importance of resolution of inflammation and how fatty acids are involved will be covered. "MCT, Ketones and Brain Energy Rescue during Aging" Abstract: Acknowledgements: SCC thanks his research team, collaborators and study participants, and CIHR, FRQS, NSERC, MITACS, the Alzheimer Society of Canada, the Alzheimer Association USA, Nestlé Health Science, Bulletproof, Abitec for financial and in-kind support of his research program. |
