LIPIDS ΩNLINE WEBINAR Molecular and Signaling Mechanisms for Neurodevelopmental and Neuroprotective Effects of Docosahexaenoic AcidThe neurodevelopmental and neuroprotective actions of docosahexaenoic acid (DHA) are mediated by mechanisms involving membrane- and metabolite-related signal transduction. A key characteristic in the membrane-mediated action of DHA results from the stimulated synthesis of neuronal phosphatidylserine (PS). The resulting DHA-PS-rich membrane domains facilitate the translocation and activation of kinases such as Raf-1, protein kinase C (PKC), and Akt. The activation of these signaling pathways promotes neuronal development and survival. DHA is also metabolized to N-docosahexaenoylethanolamine (synaptamide) that promotes neurogenesis and synaptogenesis and exerts anti-inflammatory effects. Synaptamide binds to the GAIN domain of the GPR110 (ADGRF1) receptor, triggers the cAMP/protein kinase A (PKA) signaling pathway, and activates the cAMP-response element binding protein (CREB). The DHA status in the brain influences not only the PS-dependent signal transduction but also the metabolite formation and expression of pre- and post-synaptic proteins that are downstream of the CREB activation and affect neurotransmission. The combined actions of these processes contribute to the neurodevelopmental and neuroprotective effects of DHA. Webinars are typically posted within 24 hours of completion. Presentations will be available for 30 days and then moved to the ISSFAL Members Only section of the website. |